What was the method of dietary intervention in the Fasting Mimicking Diet study?

The Fasting Mimicking Diet (FMD) study utilized a method that involved a structured dietary program lasting four days, designed to mimic the effects of fasting while still allowing for the intake of certain nutrients. This approach consists of a very low-calorie intake that is specifically formulated to provide essential nutrients while promoting a state of metabolic change similar to fasting. During the four days of the intervention, participants consume a diet that typically is low in carbohydrates, protein, and calories, which helps to initiate physiological responses associated with fasting, including cellular regeneration and autophagy.

This dietary intervention has been studied for its effects on health markers such as inflammation, metabolism, and overall well-being. The design of a four-day period allows for significant metabolic shifts without the potential downsides or difficulties often associated with complete fasting for extended periods.

The focus on mimicking fasting rather than simply restricting caloric intake in a more conventional way is what makes this diet unique and beneficial for research into fasting-related health benefits.