Which of the following is a key factor associated with the management of Type 2 Diabetes Mellitus (T2DM)?

Insulin therapy plays a vital role in the management of Type 2 Diabetes Mellitus (T2DM), particularly in cases where oral medications are insufficient to maintain blood glucose control. While many individuals with T2DM can initially manage their condition with lifestyle modifications and oral hypoglycemic agents, as the disease progresses, the pancreas may produce less insulin, necessitating the addition of insulin therapy to help achieve optimal glycemic control. Insulin can help reduce blood glucose levels effectively when other treatment options are not adequate, making it a crucial element in the management of this condition.

In contrast, while dietary restrictions, gender differences, and the age of diagnosis all play a role in diabetes management and disease progression, they are not the primary tools used to directly manage blood glucose levels in the same way that insulin therapy does. Dietary changes are important for overall health and glucose control, but they are part of a broader lifestyle approach, rather than a key therapeutic intervention like insulin. Gender differences and age of diagnosis can influence the approach to treatment and the disease's trajectory but do not directly impact glucose management as insulin does.